rbpj - Wikilingue - Encydia
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| Estrutura tridimensional da proteína RBPJ. | |
| Proteína de unión a TATA
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| Identificadores | |
| Símbolo | RBPJ |
| Símbolos alt. | CBF1; IGKJRB; IGKJRB1; KBF2; MGC61669; RBP-J; RBPJK; RBPSUH; SUH; csl |
| Entrez | 3516 |
| HUGO | 5724 |
| OMIM | 147183 |
| PDB | 2f8x |
| RefSeq | NP_005340 |
| UniProt | Q06330 |
| Outros datos | |
| Locus | Cr. 4 p15.2 |
A proteína recombinante de unión supresora de calvicie (RBPJ) é unha proteína codificada en humanos polo xene RBPJ.[1] [2] [3]
RBPJ,[4] tamén coñecida como CBF1, é un homólogo do xene de Drosophila O seu(H) (supresor de calvicie). É clásicamente usado como unha rexión promotora para demostrar a existencia da ruta de señalización Notch.[5]
Interaccións
A proteína RBPJ demostrou ser capaz de interaccionar con:
Referencias
- ↑ Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi E, Matsuda F, Kawaichi M, Honjo T (Oct 1993). «[Expresión errónea: operador < inesperado Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue]». Genomics 17 (2): pp. 306–15. doi:. PMID 8406481.
- ↑ Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (Nov 1997). «[Expresión errónea: operador < inesperado Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization]». Jpn J Hum Genet 42 (2): pp. 337–41. PMID 9290259.
- ↑ «Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region».
- ↑ «Human Genome Organization: RBPJ Report».
- ↑ Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (1996). «[Expresión errónea: operador < inesperado Truncated mammalian Notch1 activates CBF1/RBPJk-repressed xenes by a mechanism resembling that of Epstein-Barr virus EBNA2.]». Molecular and Cellular Biology 16 (3): pp. 952–959. PMID 8622698.
- ↑ Kurooka, H; Honjo T (Jun. 2000). «[Expresión errónea: operador < inesperado Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5]». J. Biol. Chem. (UNITED STATES) 275 (22): pp. 17211–20. doi:. ISSN 0021-9258. PMID 10747963.
- ↑ Beatus, P; Lundkvist J, Oberg C, Pedersen K, Lendahl Ou (Jun. 2001). «[Expresión errónea: operador < inesperado The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity]». Mech. Dev. (Ireland) 104 (1-2): pp. 3–20. ISSN 0925-4773. PMID 11404076.
- ↑ Zhou, S; Hayward S D (Sep. 2001). «[Expresión errónea: operador < inesperado Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex]». Mol. Cell. Biol. (United States) 21 (18): pp. 6222–32. ISSN 0270-7306. PMID 11509665.
- ↑ a b Zhou, S; Fujimuro M, Hsieh J J, Chen L, Hayward S D (Feb. 2000). «[Expresión errónea: operador < inesperado A role for SKIP in EBNA2 activation of CBF1-repressed promoters]». J. Virol. (UNITED STATES) 74 (4): pp. 1939–47. ISSN 0022-538X. PMID 10644367.
- ↑ Zhou, S; Fujimuro M, Hsieh J J, Chen L, Miyamoto A, Weinmaster G, Hayward S D (Apr. 2000). «[Expresión errónea: operador < inesperado SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function]». Mol. Cell. Biol. (UNITED STATES) 20 (7): pp. 2400–10. ISSN 0270-7306. PMID 10713164.
- ↑ Nam, Yunsun; Weng Andrew P, Aster Jon C, Blacklow Stephen C (Jun. 2003). «[Expresión errónea: operador < inesperado Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex]». J. Biol. Chem. (United States) 278 (23): pp. 21232–9. doi:. ISSN 0021-9258. PMID 12644465.
- ↑ Aster, J C; Robertson E S, Hasserjian R P, Turner J R, Kieff E, Sklar J (Apr. 1997). «[Expresión errónea: operador < inesperado Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription]». J. Biol. Chem. (UNITED STATES) 272 (17): pp. 11336–43. ISSN 0021-9258. PMID 9111040.
- ↑ Hsieh, J J; Zhou S, Chen L, Young D B, Hayward S D (Jan. 1999). «[Expresión errónea: operador < inesperado CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex]». Proc. Natl. Acad. Sci. Ou.S.A. (UNITED STATES) 96 (1): pp. 23–8. ISSN 0027-8424. PMID 9874765.
